Previous studies have demonstrated that osteopontin, a proinflammatory cytokine, has an important role in the pathogenesis of rheumatoid arthritis (RA). To exploit osteopontin as a potential ...

肾毒性机制：与其在肾皮质，尤其是近曲小管细胞中的积累有关。这些药物可损伤刷状缘膜的完整性，导致细胞内钙稳态失衡、线粒体功能障碍、增加氧化应激，最终引起细胞损伤和凋亡。在分子水平上，氨基糖苷类还能与细胞内的磷脂和蛋白质相互作用，干扰细胞的正常代谢活动。

The US Food and Drug Administration (FDA) has lifted the partial clinical hold on Vigil Neuroscience’s Phase I trial of ...

Human milk osteopontin (OPN) is a bioactive protein found in breast milk that undergoes extensive post-translational processing to achieve its functionality. There is strong evidence that OPN in ...

Breast milk is, scientists now know, made of unique human proteins, sugars and fats, capable of delivering not only nutrition ...

During a 2004 study by Swedish biotech Follicum on arteriosclerosis (narrowing of the arteries), researchers discovered that osteopontin – a bone sialoprotein – stimulated hair growth. It led to the ...

The molecule in question is called osteopontin. It is found in a cluster of melanocytes that also have hairs growing out of ...

Explains Tran, “we came into contact with Dr. Bo Lonnerdal...a milk protein expert and he pointed out that osteopontin was one of the [breastmilk proteins] he felt was really powerful ...

F.M. Yavitt, B.E. Kirkpatrick, M.R. Blatchley, K.F. Speckl, E. Mohagheghian, R. Moldovan, N. Wang, P.J. Dempsey and K.S. Anseth, “In situ modulation of intestinal ...

Importantly, VG-3927 achieved a robust and sustained decrease of soluble TREM2 in the CSF demonstrating clinical proof-of-target engagement. VG-3927 also showed an increase in osteopontin/secreted ...

This study aimed to establish relations between calcified deposits in renal papillae and the development and morphology of corresponding COM papillary renal calculi.

Vigil Neuroscience, Inc. (Nasdaq: VIGL), a clinical-stage biotechnology company committed to harnessing the power of microglia for the treatment of ...