The p53 pathway responds to various cellular stress signals by triggering the p53 protein, which mediates the transcriptional activation or repression of a host of target genes. We present and ...

There is extensive crosstalk between the Rb–E2f and MDM2–p53 pathways, and specifically between the transcription factors E2F1 and p53, which influences vital cellular decisions. The abundance ...

Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...

CaMKII activates the HRI/eIF2α signaling pathway and inhibits the proteotoxicity induced by proteasome inhibition through ...

With respect to a possible predictive or prognostic utility of altered hedgehog network gene expression, expression of PTCH1 or SMO did not correlate with histological grade (DCIS only) or with ...

However, whether BCAS2 has other functions within the nucleus remains largely unknown. Here, we show that BCAS2 is essential for primitive hematopoiesis in zebrafish and mouse embryos. The activation ...