AKT signaling pathway is one of the most critical and extensively investigated signaling pathways. It is the central ...

10月16日，国际心脏研究学会官方杂志Journal of Molecular and Cellular Cardiology在线发表了中国科学院上海营养与健康研究所杨黄恬研究团队题为“Human embryonic stem cell-derived cardiovascular progenitor cells stimulate cardiomyocyte cell cycle ...

*仅供医学专业人士阅读参考ctDNA监测有望为晚期ER+乳腺癌治疗耐药后进展提供早期预警。过去十年中，晚期雌激素受体阳性（ER+）乳腺癌取得了重大进展[1]。内分泌治疗及细胞周期蛋白依赖性激酶4/6抑制剂（CDK4/6i）的发展和应用显著延长了患者无 ...

2024 年 11 月 6 日，我院 天然药物及仿生药物全国重点实验室 PI 崔一民教授团队与刘振明研究员团队合作在 Advanced Science 发表了最新研究成果 “Targeting SLITRK4 Restrains Proliferation and Liver Metastasis in Colorectal Cancer Via Regulating PI3K/AKT/ NFκB ...

*仅供医学专业人士阅读参考一项韩国回顾性分析揭示PIK3CA基因突变在原发灶与转移灶间总体一致率达87.8%。乳腺癌作为全球女性中最常见的恶性肿瘤[1]，其早期诊断与治疗对改善患者预后至关重要。HR+/HER2-乳腺癌约占总体乳腺癌的70%[2]，而 ...

The phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway is one of the most critical and extensively investigated signaling pathways. It is the central regulator of various cellular ...

Cancer remains one of the leading global causes of mortality, with an estimated increase in cases due to lifestyle, ...

Cancer remains one of the leading global causes of mortality, with an estimated increase in cases due to lifestyle, environmental, and genetic ...

The company’s lead development candidate is Paxalisib, a small molecule, brain-penetrant inhibitor of the PI3K/AKT/mTOR pathway, which is developed as a potential therapy for glioblastoma.