In 1935, in Minshall Laboratory, DePauw alumnus Percy L. Julian (1899-1975) first synthesized the drug physostigmine, previously only available from its natural source, the calabar bean. His ...

who described in vivid detail the work he'd done as a DePauw undergraduate 65 years earlier to assist Julian in his famous battle with Oxford's Robert Robinson over the synthesis of physostigmine.

He returned to the States, ready to launch a career in chemistry (including later, seminal work using another alkaloid called physostigmine from the calabar bean, left). Chemical tour de force ...

Total synthesis of physostigmine at DePauw's Minshall Lab, 1935 Developed soya phosphaticles, a widely used food supplement; fire-fighting foam made from soybean oil (called bean soup); and ...

Intravenous physostigmine, flumazenil, or both may be used in severe cases. Repeated dosing may be needed, because these agents have a shorter half-life than baclofen. Dantrolene is unique among ...

Effects are reversible by treatment with carbamates (such as physostigmine) which are inhibitors of the enzyme acetylcholinesterase.155 Signs and symptoms of LSD intoxication include rapid heart ...

Due, in part, to the logical nature of the approach, combination therapy is already widely used in clinical practice. Although compounds with a combined cholinergic–glutamatergic action have ...

Cholinesterase inhibitors like physostigmine, neostigimine due to decreased efficacy of these drugs.

[PubMed] [Content] Reed SJ, Plourde G, Tobin S, Chapman CA (2013) Partial antagonism of propofol anaesthesia by physostigmine in rats is associated with potentiation of fast (80-200 Hz) oscillations ...