although the latter can be stabilized and protected by single-strand DNA binding proteins. Researchers have recently discovered that, in eukaryotes, the replication protein A (RPA) is a form of ...

We are interested in the mechanism of chromosome replication, a process that is highly conserved across eukaryotes and that involves the duplication of both the chromosomal DNA and its associated ...

During DNA replication, special enzymes move up along the DNA ladder, unzipping the molecule as it moves along. New nucleotides move in to each side of the unzipped ladder. The bases on these ...

Eukaryotic cell DNA in a nucleus, plasmids are found in a few simple eukaryotic organisms. Prokaryotic cell DNA is a single molecule, found free in the cytoplasm; additional DNA is found on one or ...

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified. A protein that is involved in determining which enzymes cut or unwind ...

This process is essential for the proper functioning and survival of all living organisms. DNA replication is the process by which the DNA molecule makes an exact copy of itself during cell division.

DNA is susceptible to damage caused by errors committed during replication and by environmental factors, such as radiation, oxidants, or alkylating agents. Repair reactions involve the excision of ...

Bacteria are amongst the simplest of organisms – they are made of single cells. Their cell structure is simpler than the cells of animals, plants and fungi.

Arrested replication forks are prone to collapse, posing serious threats to genomic integrity, suggesting that DNA replication problems are critical drivers of genomic ... control and genome ...

POLK expression in neurons and report an important observation that POLK exhibits an age-dependent change in subcellular localization, from the nucleus in young tissue to the cytoplasm in old tissue.

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified in a new study. The antibody-drug conjugate (ADC) puxitatug samrotecan ...