For almost a century, our understanding of the tiny structure at the centre of the cell called the centrosome was limited to its ability to organize mitotic spindles and other microtubule arrays.

The resulting cells, locked together like Siamese twins, would have twice as many chromosomes and centrosomes, making them unfit and prone to malignancy. Many cancer cells, for example ...

and a drug combination to restore contact inhibition of proliferation. The other three programs focus on centrosome declustering therapy, tumor suppressor synthetic lethality and polyploid cell ...