Spermidine is a natural polyamine found in cells whose post-translational acetylhypusination regulates key proteins like receptor-interacting serine/threonine-protein kinase 1 (RIPK1). Aging ...

Sironax' lead RIPK1 drug, SIR0365, has completed two phase 1b studies including one looking at its potential as a treatment for severe hyperinflammation associated with COVID-19 infections, while ...

The lab-grown organoids allowed the team to gain a new understanding of how one genetic mutation leads to autism spectrum disorder. It also showed that an experimental drug, called NitroSynapsin ...

Organoids’ ability to replicate aspects of the structure and function of larger tissues and organs makes them effective tools for studying diseases with complex etiologies as well as inherited ...