and HB-GAM (heparin-binding growth-associated molecule; pleiotrophin). In addition to heparin/heparan sulfates, HMGB1 binds to the immunoglobulin superfamily protein RAGE (receptor for advanced ...

First, peripheral levels of RAGE ligands, such as S100/calgranulins, AGEs and HMGB1, can be reduced ... In general, ligand binding to RAGE initiates cellular activation and receptor-dependent ...

Two functional types of RAGE have been associated with neurological diseases: cell membrane-bound (full length) and soluble. In general, ligand binding to full-length RAGE initiates sustained ...

Horrifying footage shows the moment a cyclist was hurled to the ground in a disturbing display of road rage. The video, which has been widely shared across social media, shows the cyclist being ...

Makes you tense up just to read it, doesn't it? One study estimates that more than half of all drivers have experienced a surge of road rage at some point, although not all bang into the offender ...

Treatment of mice with oleocanthal has been found to restore the blood-brain barrier integrity, increase autophagy, prevent neuroinflammation, suppress the RAGE/HMGB1 pathway, restore brain ATP ...

ORINDA, Calif. - Authorities have identified the man who was shot following a heated road rage incident that sent shockwaves in Orinda. The victim was identified as 50-year-old Scott Patrick ...

We acknowledge Aboriginal and Torres Strait Islander peoples as the First Australians and Traditional Custodians of the lands where we live, learn and work.

We acknowledge Aboriginal and Torres Strait Islander peoples as the First Australians and Traditional Custodians of the lands where we live, learn and work.

In recent days alone, a motorist in Valley View, OH was killed in an act of road rage; in Indianapolis, IN an armed man angrily approached a pickup truck with gun in hand, only to be shot by the ...