the major downstream RAS effectors PI3K, RAF and RAL–GEF and cytokine signaling pathways. Examples of clinical-stage small-molecule kinase inhibitors that target each signaling axis are also ...

The MAP kinase family includes the extracellular-signal related kinases (ERKs), which signal through a pathway involving sequential activation of Ras, Raf and mitogen-activated protein kinase ...

The known downregulated RAS pathway targets include the genes encoding α-actin, collagen α-1, entactin/nidogen, fibronectin, TGFß-stimulated sequence TSC-36, lysyl oxidase, smooth muscle myosin ...

We played an important role in revealing the biochemical steps of the RAS-RAF-MAP kinase pathway. We discovered one of the major ways by which RAS oncogenes cause normal cells to become cancerous – ...

Candel Therapeutics (CADL) announced preclinical results and therapeutic potential of CAN-3110 in the Ras-Raf pathway altered melanoma model. The data will be presented at the Society for ...

Immuneering Corp. Class A ( (IMRX) ) has released its Q3 earnings. Here is a breakdown of the information Immuneering Corp. Class A presented ...