The first CF rat model, CFTR tm1sage (termed CFTR-/- or KO), was designed in collaboration with SAGE (now Horizon Discovery) and subsequently characterized at UAB and distributed to the CF community.

Five groups are now working together to assemble, annotate and release an updated version of the rat genome. As the prevailing model for physiology, complex disease and pharmacological studies ...

Transgenic human tau was sufficient to induce tau pathology and neurodegeneration in this rat model. Tg12099; Mapt-/-rats developed tau pathology—including neurofibrillary tangles—and exhibited ...

The rat is the preferred model organism in many fields of biomedicine, such as toxicology testing. But when it comes to disease models, rats have been upstaged by mice, which traditionally were ...

In a new study, researchers have developed a comprehensive in silico model of the rat hippocampal CA1 region. This model is ...

The Newcells aProximateTM near-physiological kidney transporter model provides cross-species comparison of drug handling.

Low-extremity ischemic disease is a common complication in diabetic patients, leading to reduced quality of life and potential amputation. This study investigated the therapeutic effect of spinal cord ...