The connection between the drugs and kidney problems has long been known, but how and why that happens has been a mystery ...

The class of drugs, known as renin–angiotensin system (RAS) inhibitors, block the effects of the renin enzyme, relaxing blood ...

Drug-induced AKI (acute kidney injury) is common and may include medications not previously known to exhibit this safety signal.

High blood pressure, or hypertension, affects nearly half of all Americans, and many are unaware they have it. This condition ...

Prolonged use of renin-angiotensin system (RAS) inhibitors, common in hypertension treatment, can harm kidneys, leading to scarring, vascular changes and impaired filtration. Researchers found ...

Scientists have discovered how long-term treatment of high blood pressure with commonly prescribed drugs can destroy the kidney's ability to filter and purify blood. The finding could open the door to ...

Researchers at the University of Virginia School of Medicine say this finding could open the door to better ways to manage ...

If the clinical history is not helpful (e.g., there is no documentation of the efficacy of drug "A ... a reactive renin system should have an increased renin while on ACE inhibitor therapy.

Hypertension (high blood pressure) affects an estimated 1 billion people worldwide and approximately 65 million people in the US alone. If not treated effectively, this common disorder can lead to ...

Several screening tests for renal vascular hypertension that utilize pharmacological inhibitors ... antihypertensive drug therapy, since the usual effect of drugs on both renin and aldosterone ...