It is an ester-derived prodrug that is converted in vivo by serum and tissue esterases to tenofovir, an acyclic nucleoside phosphonate (nucleotide) that inhibits HIV reverse transcriptase.

CRF: Circulating recombinant form; NNRTI: Non-nucleoside reverse-transcriptase inhibitor; NRTI: Nucleos(t)ide analog reverse-transcriptase inhibitor. Eight nucleos(t)ide analog reverse ...

Sequence variations in human immunodeficiency virus (HIV)-1 reverse transcriptase (RT) and protease, the molecular targets of anti-retroviral drug therapy, are prime examples of genes in which ...

Rome Therapeutics Inc. has presented data demonstrating the potential of its LINE-1 reverse transcriptase (RT) inhibitors.

1). It belongs to the class of nucleoside reverse transcriptase inhibitors (NRTIs), which have been at the forefront of antiretroviral therapy ever since. Figure 1: Timeline of the development of ...

The four main classes, which most people are treated with, target one of three viral proteins which control HIV’s lifecycle: reverse transcriptase, integrase and protease. Historically, most people ...

More than 46,000 of them had been prescribed a form of HIV-suppressing medications known as reverse transcriptase (RT) inhibitors. Among this subgroup, Alzheimer's diagnoses occurred in about 2.5 ...

They use an enzyme called reverse transcriptase, just like the human immunodeficiency virus (HIV), to replicate themselves. Humans have evolved mechanisms to keep retrotransposons turned off most ...

If you enjoy eating red meat, you might want to pay attention to new research linking it to cancer risk. A recent study ...

The new data – presented at the IDWeek congress yesterday – found that the pairing of MSD's experimental nucleoside reverse transcriptase translocation inhibitor islatravir with Gilead's ...

This fixed-dose tablet combines 600mg efavirenz, 200mg emtricitabine (FTC), and 245mg tenofovir disoproxil fumarate (TDF). Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI), ...

Australia: A recent study published in Clinical Infectious Diseases has shown that the current use of integrase strand ...