This issue is even more of a concern when analogous dominant-inhibitory versions of Rho-family GTPases, such as Rho, Rac and Cdc42, are used. Many of the nucleotide-exchange factors for these ...

The RAS superfamily of GTPases includes five major subfamilies of monomeric guanine nucleotide binding proteins (RAS, RHO, RAB, RAN and ARF), which possess GDP/GTP-binding and intrinsic GTPase ...

Keywords regulation of intracellular traffic and the actin cytoskeleton by rho family gtpases Areas of expertise Rho GTPases act as molecular switches that control a wide range of signalling pathways ...

Rho GTPases are molecular switches that control the cytoskeleton. The spreading of cancer cells from one part of the body to another, called metastasis, is one of the main causes of cancer death. To ...