This issue is even more of a concern when analogous dominant-inhibitory versions of Rho-family GTPases, such as Rho, Rac and Cdc42, are used. Many of the nucleotide-exchange factors for these ...

Molecules called Rho-family GTPases act as biochemical switches that couple cytoskeletal organization to distinct environmental signals regulate these shape changes. Rho guanine nucleotide exchange ...

Keywords regulation of intracellular traffic and the actin cytoskeleton by rho family gtpases Areas of expertise Rho GTPases act as molecular switches that control a wide range of signalling pathways ...

Rho GTPases are molecular switches that control the cytoskeleton. The spreading of cancer cells from one part of the body to another, called metastasis, is one of the main causes of cancer death. To ...