A research team has unveiled an adrenal independent pathway, the hypothalamus-sympathetic-liver (HSL) axis, to mediate stress-induced glucose release. Their study is published in Nature ...

The protein deacetylase SIRT1 is an important mediator of the beneficial effects of calorie restriction on lifespan, glucose homeostasis and insulin sensitivity. As these beneficial effects can be ...

Second, substantial evidence from preclinical work suggests that resveratrol stimulates SIRT1 activity and suppresses inflammatory pathways in ... fasting glucose, and fasting insulin.

Based on animal and in vitro studies, resveratrol reverts these risk factors via stimulation of silent mating type information regulation 2 homolog 1 (SIRT1), but data in human subjects are scarce.