Over 2 decades ago, the aldosterone antagonist eplerenone proved beneficial after MI complicated by left ventricular ...

Spironolactone was initiated at a dose of 25 mg daily at the first ambulatory blood pressure monitoring and titrated to 50 mg or 100 mg daily after office-based assessment of blood pressure at ...

25–50 mg daily for 1 year. Five patients taking spironolactone and one patient on placebo developed hyperkalemia within 2–12 weeks of initiation of study medication and were excluded.