Spironolactone was initiated at a dose of ... Further studies should investigate these mechanisms and confirm the associations of waist circumference and aortic pulse-wave velocity.boxed-text ...

The landmark Randomized Aldactone Evaluation Study (RALES), published in 1999, showed that spironolactone, a potassium-sparing diuretic, improves outcomes in patients with severe heart failure.

Since spironolactone’s mechanism of action is specifically for hormone-related hair loss, it won’t work for those ...