The CLEAR SYNERGY trial found that spironolactone may reduce the risk of new or worsening heart failure; however, it did not significantly impact the rate of death, new heart attack or stroke.

Spironolactone is a generic drug prescribed for certain conditions, such as high blood pressure in adults. As with other drugs, spironolactone can cause side effects, such as dizziness and high ...

Among the various treatments available, spironolactone and finasteride are two medications frequently discussed for their ...

The routine administration of spironolactone to patients after a myocardial infarction (MI) did not reduce either of the coprimary outcomes in the CLEAR SYNERGY (OASIS 9) trial. However ...

Among 203 patients, 71% of those taking SZC achieved the primary endpoint of optimal response -- normokalemia while on at least a 25-mg dose of spironolactone daily without rescue therapy for ...

Get detailed information on Furosemide and Spironolactone, including pronunciation, uses, dosage guidelines, indications, and instructions on how and when to take it and when to avoid it.

Background: Risk of morbidity and mortality in patients with severe heart failure (HF) is reduced by blockade of aldosterone receptors with spironolactone. However, benefits of spironolactone are ...

investigated whether adding the aldosterone receptor antagonist spironolactone to renin–angiotensin system inhibition improved proteinuria in patients with diabetic nephropathy. Patients with ...

The landmark Randomized Aldactone Evaluation Study (RALES), published in 1999, showed that spironolactone, a potassium-sparing diuretic, improves outcomes in patients with severe heart failure.