As the genomic regions that match the ESTs should be exons and the alignment gaps between them should be introns, the putative splice sites at their boundaries can be carefully checked.

This important manuscript provides insights into the competition between Splicing Factor 1 (SF1) and Quaking (QKI) for binding at the ACUAA branch point sequence in a model intron, regulating exon ...

“Despite the biological and pathological relevance of AS, the molecular mechanisms that regulate splice site selection remain poorly understood,” the author noted. As part of their newly ...

A new process that is essential to the synthesis of cellular proteins has been discovered by an international research team.