DRB1*11:01 was associated with an increased risk of anti-HMGCR myopathy. This study, therefore, suggests a mechanistic link between statin exposure, increased HMGCR expression and the potential ...

Important genes involved in the lipid-lowering response to statin therapy include the HMGCR and APOE genes. However, those results are equivocal and further studies are needed to explore the role ...

“It’s incredibly rare.” Myositis in general affects 50,000 to 75,000 people in the U.S., but the statin-triggered type Furlan had — called HMGCR necrotizing myopathy — is seen in only ...

Among participants in the landmark ORAL Surveillance study assigned to the JAK inhibitor tofacitinib (Xeljanz) and also using statins, major adverse cardiovascular events (MACE) were no more ...