Similarly, in a tauopathy mouse model, the more aggregated TMEM106b a neuron had, the more phosphorylated tau it accumulated. Moving beyond mice, the authors found the same pattern in postmortem brain ...

Researchers have revealed the role of enzyme TYK2 in the aggregation of tau proteins, which contributes to Alzheimer’s ...

These tau knockout rats were created through transcription activator-like effector nuclease (TALEN)-mediated targeting of exon 2 of the rat Mapt gene (Ayers, Lopez et al., 2024). Tau protein was ...