These include cooling agents, topical anesthetics, topical antihistamines, capsaicin, topical corticosteroids, and topical immunomodulators. Emollients are the first-line therapy for pruritus.

Applying topical antihistamines directly to the affected area of skin may be preferable to taking oral antihistamines due to the potential side effects of oral antihistamines. Anti-itch creams ...