Topiramate, an antiepileptic drug with potential mechanisms of action including sodium channel blockade, inhibition of glutamate receptors, and enhancement of γ-aminobutyric acid (GABA ...

After 24 weeks, the placebo group lost ... should take a baseline serum bicarbonate blood level before starting you on ...

After a mean period of 27.5 months of treatment (range 24-61 months), 11 patients (4%) were seizure free and 56 (20%) had more than 50% reduction in seizure frequency. The efficacy of topiramate ...

Get detailed information on Topiramate, including pronunciation ... The dose may be increased after 1 week to a maximum of 400 mg/day. When used in combination, dose may be increased to a maximum ...

[22,23] Indeed, after a mean period of 27.5 months ... in whom a mean of eight drugs administered before topiramate treatment had been ineffective. Moreover, further clinical studies are needed ...