【导读】结直肠癌（CRC）是全球第二大癌症相关死亡原因。虽然手术切除和免疫疗法提高了CRC患者的生存率，但转移和复发仍然是导致预后不良的主要问题。因此，探索发病机制并识别特异性生物标志物对于CRC的早期诊断和靶向治疗至关重要。

禁食与多种健康益处相关。禁食、低碳水化合物高脂肪饮食或运动等方式诱导的生酮作用，已被证实能激活多种细胞信号通路。然而，尽管经过了数十年的研究，禁食信号如何诱导蛋白质组水平的基因表达变化，从而建立起酮体产生的代谢程序，这一问题仍未得到充分阐明。

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By Tarun Sai LomteThe rise in early-onset cancers is reshaping public health priorities as scientists pinpoint environmental ...

New study reveals the surprising benefits of food antigens in suppressing tumour formation in the small intestines.

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