However, tumor vasculature is abnormal, chaotic and leaky due to the high production of angiogenic factors such as VEGF. In tumors, Dll4/Notch signaling appears to dampen (much like a resistor in ...

The ability of tumours to induce new blood-vessel formation has been a major focus of cancer research over the past few decades, and vascular endothelial growth factor (VEGF) is now known to be ...

Notch activity can counteract VEGF-C-dependent (lymph)angiogenesis in KSHV-infected lymphatic endothelial cells, further supporting the central role of Notch signaling in cell fate determination.

The VEGF family members VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, VEGF-F, and PlGF attach in distinct patterns to three related receptor protein tyrosine kinases —VEGFR1/FLT1, VEGFR2/KDR ...