Nevertheless, this study shows that targeting fungal histone acetylation using nicotinamide — which is well tolerated in humans — or future fungal sirtuin inhibitors is a novel strategy to ...

The functional diversity of HMGB1 is heavily regulated by its PTMs, including acetylation, phosphorylation, oxidation, and ...

Learn about HMGB1's crucial role in liver diseases, its pathways and therapeutic potential that can treat liver diseases.

Liver diseases, both acute and chronic, continue to pose significant clinical challenges due to high morbidity and mortality ...

Epigenetic modifications, particularly histone modifications, play a crucial role in cancer initiation and progression. These modifications, which include methylation, acetylation, phosphorylation, ...

Cancer, a disease with global impact, is intricately linked to dysregulated gene expression, which is influenced by both genetic mutations and epigenetic changes, including RNA modifications. A ...

Over four hundred people, 80% of them being children under 14 years old, will be diagnosed with B-cell Acute Lymphoblastic ...

Conventional lytic inducers, such as histone deacetylase inhibitors, are known to induce the EBV lytic cycle by promoting ...

It is a preferred venue for the latest research reports and reviews of epigenetics, iRNA mechanics, histone acetylation, nitric oxide signaling, eicosanoid biochemistry, angiogenesis, tumor ...

This important manuscript provides insights into the competition between Splicing Factor 1 (SF1) and Quaking (QKI) for binding at the ACUAA branch point sequence in a model intron, regulating exon ...

In conclusion, this intriguing report builds on the work of many other groups by further unraveling MECP2 function in the ...