The EMBO Journal2d
A shorter splicing isoform antagonizes ZBP1 to modulate cell death and inflammatory responses
Mice express full-length protein ZBP1-L as well as an alternatively-spliced shorter isoform (ZBP1-S) containing only its two ...
The EMBO Journal8d
Glutaminolysis provides nucleotides and amino acids to regulate osteoclast differentiation in mice
Metabolic rewiring is essential for osteoclast differentiation and bone resorption. This study shows that glutaminolysis ...
eLife3d
Glia-mediated gut-brain cytokine signaling couples sleep to intestinal inflammation
Sickness-induced sleep is a behavior conserved across species that promotes recovery from illness, yet the underlying mechanisms are poorly understood. Here, we show that interleukin-6-like cytokine ...
eLife5d
Pathogenic LRRK2 causes age-dependent and region-specific deficits in ciliation, innervation and viability of cholinergic neurons
Pathogenic activating point mutations in the LRRK2 kinase cause autosomal-dominant familial Parkinsońs disease (PD). In cultured cells, mutant LRRK2 causes a deficit in de novo cilia formation and ...