Through high throughput screening (HTS), the O’Malley group identified bufalin as a potent proof-of-concept SRC-3 small molecule inhibitor (SMI). Our group developed bufalin nanoparticles to reduce ...
PLoS One. 2014; 9(4):e95243. PMID: 24743578. Wang Y, Lonard DM, Yu Y, et al. Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1. Cancer Res. 2014 Mar 01; ...
Bufalin, a component from Venenum Bufonis, induced autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation [53]. Triterpenes, an ...
Keywords: Na/K-ATPase, cardiotonic steroids, bufadienolides, cardenolides, biosynthesis, chronic kidney diseases, NaCl-sensitivity, neoplasms / drug therapy, Alzheimer's disease, hypertension ...
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Abstract Maintenance of snakes at Butantan Institute started in the last century, intending to produce a different antivenom serum to reduce death caused by snakebites. Through a successful campaign ...
2-(2-Furyl)-3-hydroxychromone (HL) reacts with MII ions in the formation of quadratic [Cu(L)2] (3), octahedral [M(L)2(OH2)2] (M = Co (1), Ni (2), Zn (4), Mn (5)) and ...
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