研究人员开发了一种通过腺病毒递送转录因子 PU.1、IRF8 和 BATF3 在体内重编程肿瘤细胞的方法，这使它们能够将抗原呈递为 1 型常规树突状细胞。经过这番重编程后，肿瘤细胞可以改变其周围的肿瘤环境，吸引并增加多种细胞毒性 T ...

Field cancerization, the spread of a mutant clone that is predisposed to cancer growth prior to tumor growth, can be involved in tumorigenesis in every gastrointestinal compartment. These protumor ...

这项研究揭示了乳腺癌发生和正常组织防癌相关的不少奥秘，不过Nature同步发表的评论文章和研究者们指出了同一点，即人类乳腺相比小鼠要复杂得多，未来还需要开展转化研究，来验证研究结论是否能在人体内复现。

While the aforementioned studies show clear evidence of field cancerization, the mechanisms by which clones spread and produce a tumorigenic mutant field are not well understood. In glandular ...

A team of researchers at the VIB-KU Leuven Center for Cancer Biology, the Netherlands Cancer Institute and Oncode Institute ...

Reference: Ciwinska M, Messal HA, Hristova HR, et al. Mechanisms that clear mutations drive field cancerization in mammary tissue. Nature. 2024;633(8028):198-206. doi: 10.1038/s41586-024-07882-3 This ...