Endothelin (ET) is a recently discovered 21-amino acid peptide that has potent physiologic and pathophysiologic effects that appear to be involved in the development of heart failure. These ...

ASCEND was a multicenter, placebo-controlled trial that aimed to investigate the effects of the endothelin-A (ET A) receptor antagonist avosentan in patients with diabetic nephropathy. The study ...

Article Google Scholar Edery P, Attié T, Amiel J, Pelet A, Eng C, Hofstra RMW, Bidaud C, Munnich A, Lyonnet S: Mutation of the endothelin-3 gene in the Waardenburg-Hirschsprung disease.

The efficacy and safety of the selective endothelin type A receptor antagonist atrasentan in reducing proteinuria in patients with IgA nephropathy are incompletely understood. We are conducting a ...

Endothelin is a peptide hormone known for its vasoconstrictive effects. Researchers at University of Tsukuba used cryo-electron microscopy to examine the complex structure of the endothelin ...

Allschwil, Switzerland – November 11, 2024 Idorsia Ltd (SIX: IDIA) today announced that new data on aprocitentan, the ...

To effectively adapt to change, living organisms rely on their ability to rapidly detect and process sensory information in ...

Atrasentan previously demonstrated efficacy in the open-label AFFINITY basket trial, where it reduced the 24-hour urinary ...

Atrasentan is associated with a significant and clinically meaningful reduction in proteinuria compared with placebo in ...

One type of drug used to treat PAH is endothelin receptor antagonists. ERAs, as they are called, help keep blood vessels from narrowing. But these drugs don’t work as well for Black patients as ...

Allschwil, Switzerland – October 16, 2024 Idorsia Ltd (SIX: IDIA) today announced that new data on aprocitentan, Idorsia’s endothelin receptor antagonist, will be presented at the American Society of ...

Zibotentan acts by blocking growth receptors called endothelin receptors. It binds selectively to the ET-A receptor, thereby inhibiting endothelin-mediated mechanisms that promote cell proliferation.