His lab first discovered that excitotoxicity might be a common pathophysiological process in sporadic ALS, which led to ...

Pathologically high levels of extracellular glutamate can cause excitotoxicity, when postsynaptic receptors such as NMDA and AMPA are overactivated, allowing high levels of calcium influx that trigger ...

These findings suggested that inflammation and excitotoxicity could play a role in secondary brain injury (Castillo et al., 2002; Mayer & Rincon; Rincon & Mayer, 2004). Another theory suggests ...

The antipsychotic drug haloperidol is often used in emergency care to treat psychoses induced by methamphetamine, but a recently published animal study by Hatzipetros et al. warns that this ...

The researchers for the new study also noted that riboflavin is known to improve "oxidative stress, mitochondrial dysfunction, neuroinflammation, and glutamate excitotoxicity," all of which are ...

PROG and its metabolites can upregulate gene activity through their direct actions on the PROG intranuclear receptor, but they can also act at the NMDA receptor to reduce excitotoxicity and at the ...

In recent years, peptides have emerged as critical players in various fields of biological and molecular research. Among ...

Chapp AD, Behnke JE, Driscoll KM, Fan Y, Hoban E, Shan Z, Zhang L, Chen QH*. Acetate Mediates Alcohol Excitotoxicity in Dopaminergic-Like PC12 Cells. ACS Chem Neurosci 2019 Jan 16;10(1):235-245. 6. Wu ...

Leptomeningeal inflammation in a mouse model of multiple sclerosis triggers deeply penetrating gene changes in underlying brain tissue, described using spatial transcriptomics.

Two faculty members at the Johns Hopkins University School of Medicine and the Johns Hopkins Bloomberg School of Public Health have been elected to the National Academy of Medicine (NAM), an independe ...