This review discussed experimental mouse models used in the pre-clinical study of liver fibrosis regression, a pivotal ...

These facts point to the important notion that results obtained with various models of experimental fibrogenesis cannot be generalized because different classes of (myo-)fibroblasts are generated ...

This will be changed by increasing knowledge of new pathogenetic mechanisms, which complement the "canonical principle" of fibrogenesis. The latter is based on the activation of hepatic stellate ...

Collagen-producing activated myofibroblasts, which are key effector cells in fibrogenesis in different organs, express high ...

Mitchell et al. induced fibrogenesis in transgenic mice that expressed the oncogene Bcl2 (encoding a membrane protein with mitochondrion-specific antioxidant properties) in their hepatocytes ...

The company, which was spun out of FibroGenesis in 2021, is using the direct public offering (DPO) route – in other words, it is raising capital directly without a firm commitment from an ...

We also discovered Podocan, an upregulated gene in the setting of HIVAN. Podocan belongs to the small leucine-rich repeat proteins (SLRP), a group of extracellular matrix genes which regulate growth, ...

Cessation of exercise reversed the fibrotic changes. The question is whether fibrogenesis can also be prevented in man with much longer-standing exercise history. Moreover, it remains to be seen ...

2. Liver function decreases with age And that’s not all when it comes to alcohol and menopause. "Low oestrogen [which occurs as a result of menopause] may promote liver fibrogenesis, which leads to ...