One especially important class of adhesive molecules is the integrins. Integrins are more than just mechanical links, however: They also relay signals both to and from cells. In this way ...

Pliant Therapeutics, Inc. (Nasdaq: PLRX), today announced that Keith Cummings, M.D., Chief Financial Officer, and Greg ...

PLN-101095 is an oral, small molecule, dual selective inhibitor of αvβ8 and αvβ1 integrins designed to block TGF-β activation ...

Figure 1: α v β 3 as a mediator of antiangiogenic regulators. Figure 2: Trans-dominant inhibition of proangiogenic integrins. In presenting these models for negative regulation by α v integrins ...

Morphic Therapeutic has lost Johnson & Johnson's Janssen Pharma as a partner, following the termination of an alliance to develop drugs targeting integrins first agreed in 2019. In a filing with ...

The Fagerholm group studies the role of leukocyte integrins in various immune reactions. We are interested in the in vivo roles and regulation of leukocyte beta2-integrins in a healthy and ...

Using conditional mutagenesis we have determined that integrins, dystroglycan and RhoGTPAses are required for radial sorting because they induce cytoskeletal rearrangements that allow the generation ...

发烧和身体酸痛作为生物长期进化以来产生的免疫系统外挂，保障身体及时对内外环境变化做出反应。下丘脑的体温调节为免疫系统击溃来犯之敌提供了坚实的后勤保障，而参与作战的诸多免疫细胞，一部分在对抗病原菌入侵时牺牲，一部分也会在大战落幕后结束生命，这不仅能够防 ...

Kindlin-2 acts as a physical bridge that links TGFbR1 and Integrins to activate the non-canonical TGF-β oncogenic signaling. In the nucleus, Kindlin-2 associate with p53 to regulate cancer cell ...

Using cell model systems and genetically engineered mice, we have shown that ST6Gal-I-mediated sialylation controls the function of select integrins, growth factor receptors and death receptors.

Shares of Pliant Therapeutics, Inc. (NASDAQ:PLRX – Get Free Report) have earned an average recommendation of “Buy” from the nine analysts that are covering the firm, Marketbeat Ratings reports. Eight ...

Meanwhile, Dice’s pipeline also includes programmes targeting integrins, with potential in inflammatory bowel disease and fibrosis, and PD-L1, which could lead to an oral alternative to ...