引言适应性是任何物种生存的根本。在复杂的微环境中，细菌会面临许多压力，包括营养和生态位竞争、氧化和氮化压力或抗生素。为了克服这些挑战，细菌可能会激活特定的应答程序，这些程序通过改变转录或翻译的表达模式来促进其在这些条件下的生存。此外，细菌子细胞可能会 ...

The p73 protein, a homologue of the tumour-suppressor protein p53, can activate p53-responsive promoters and induce apoptosis in p53-deficient cells. Here we report that some tumour-derived p53 ...

The focus has until now been on two pathways by which suppressors become disabled: intragenic mutations and loss of chromosomal material (loss of heterozygosity (LOH) or homozygous deletion).

The situations when the amplification breakpoint is not acceptable (Figure 2): (1) Multiple intragenic breakpoints; (2) The candidate is not the gene closest to the amplification breakpoint; (3) The ...

Despite diagnostic and therapeutic advances, mortality and the multi-systemic health impact of SMA continue to be experienced ...

Although tumour cells gain a series of characteristics that provide a selective advantage, the mutational events that drive these processes also impart upon the cell a series of dependencies. One ...