In eukaryotes, the process of mRNA decay generally involves loss of the 3′ poly(A) tail and removal of the cap by a decapping enzyme (Dcp2). The body of the mRNA is then degraded from the 5 ...

An estimated one-third of mutations underlying human disorders result in premature termination codons, which subsequently lead to rapid degradation of the mutant mRNA by the NMD pathway 1,2,3.

More information: Alexander Kögel et al, Structural basis of mRNA decay by the human exosome–ribosome supercomplex, Nature ...