tRNAs help some mRNAs get lost in translation
Scientists have discovered that tRNAs can determine how long mRNAs exist in a cell, causing some messages to be stabilized ...
The EMBO Journal10d
Subcellular mRNA kinetic modeling reveals nuclear retention as rate-limiting
Transcriptome-wide measurement of subcellular mRNA dynamics in mouse ES cells reveals that nuclear retention is the ...
Hosted on MSN8mon
Boosting mRNA activity and longevity with multi-tailed structures
In 2022, they showed that chemically modifying the poly(A) tail slows down the natural decay of mRNA, rendering it more useful for a wider range of therapies. They named those modified molecules "mRNA ...
Taiwan News7h
ReviR Therapeutics and Kennedy's Disease Association Partner to Advance Treatment for Rare Neuromuscular Disorder
The collaboration aims to identify a small molecule that targets mutant androgen receptor (AR) mRNA splicing and causes selective destruction of the disease-causing mRNA. By modulating mRNA splicing, ...
High-resolution structural data shows how a supercomplex links mRNA translation and decay
More information: Alexander Kögel et al, Structural basis of mRNA decay by the human exosome–ribosome supercomplex, Nature ...
Nature9y
The end defines the means in bacterial mRNA decay
In eukaryotes, the process of mRNA decay generally involves loss of the 3′ poly(A) tail and removal of the cap by a decapping enzyme (Dcp2). The body of the mRNA is then degraded from the 5 ...