科学家发现，转运 RNA (tRNA) 能够决定信使 RNA（mRNA）在细胞中的寿命，导致某些 mRNA 被稳定保存并翻译成更多的蛋白质，而另一些 mRNA 则被降解，从而限制蛋白质的生成量。

In eukaryotes, the process of mRNA decay generally involves loss of the 3′ poly(A) tail and removal of the cap by a decapping enzyme (Dcp2). The body of the mRNA is then degraded from the 5 ...

Scientists have discovered that tRNAs can determine how long mRNAs exist in a cell, causing some messages to be stabilized ...

More information: Alexander Kögel et al, Structural basis of mRNA decay by the human exosome–ribosome supercomplex, Nature ...

The collaboration aims to identify a small molecule that targets mutant androgen receptor (AR) mRNA splicing and causes selective destruction of the disease-causing mRNA. By modulating mRNA splicing, ...

plays an important role in protecting mRNA from degradation inside cells. In 2022, they showed that chemically modifying the poly(A) tail slows down the natural decay of mRNA, rendering it more useful ...