近日,广东省人民医院鲁冰、赵蔚团队在《Nature Cancer》上发表了题为“Phase separation of phospho-HDAC6 drives aberrant chromatin architecture in triple-negative breast cancer”的文章。该论文首次揭示了三阴性乳腺癌(TNBC)中存在磷酸化HDAC6蛋白形成的凝聚体,并提出了通过干预磷酸 ...
Pathogenic activating point mutations in the LRRK2 kinase cause autosomal-dominant familial Parkinsońs disease (PD). In cultured cells, mutant LRRK2 causes a deficit in de novo cilia formation and ...
These cells deploy complex cytoskeletal rearrangements to recognize and eliminate potential threats 3. Even in the steady state, myeloid cells constantly survey their surroundings for potential ...