Role in Recombinational Repair and Double-Strand Break Repair Recombinational repair mechanisms are critical for managing ...

Bacteria frequently encounter adverse environmental conditions, such as nutrient scarcity and antibiotic exposure, which can induce DNA damage ...

Westmoreland, J. et al. RAD50 is required for efficient initiation of resection and recombinational repair at random, gamma-induced double-strand break ends. PLoS Genetics 5, e1000656 (2009).

Gene conversion - the process during which homologous sequences are made identical also falls under genetic recombination. Genetic recombination and recombinational DNA repair also occurs in bacteria ...

Currently, we are focusing on two related areas: (1) the mechanism of DNA homology search and strand transfer promoted by the human recombinational proteins, Rad51 and Rad54. (2) The purification and ...