The investigators studied the membrane-targeting sequence (MTS) of bactofilin A (BacA) in Caulobacter crescentus to explore its role in membrane binding and polymerization. They used various ...
This valuable study uses robust time-dependent microscopy assays to show that during HIV-1 infection, the viral accessory protein Vif causes cell cycle arrest during metaphase and not G2/M as ...
Researchers from Qingdao University described the discovery and preclinical characterization of a novel series of tubulin polymerization inhibitors that led to the identification of [I] as the most ...
ALE.P02 involves a CLDN-1-targeted antibody linked to a tubulin inhibitor, and ALE-P03 involves a CLDN-1-targeted antibody linked to a topoisomerase I inhibitor. OrbiMed, Novo Holdings, and Jeito ...
The sequence of amino acids in the chain determines how the chain will fold up to make the protein, so different proteins have different three-dimensional shapes. The three-dimensional shape of a ...