At the second international workshop on hematopoietic stem cells Footnote 1 (HSC), 36 experts came together to report the latest results on: self renewal, mobilization and homing of HSC ...

Nothing lives forever, but compared to other cells in the body, hematopoietic stem cells (HSCs ... the molecular mechanisms that contribute to HSC aging not only contributes to the field of ...

a gene highly active in proliferating fetal hematopoietic stem cells. HMGA2 has been well known for its role in binding to DNA and modifying chromatin structure to activate gene expression.

The primary objective of this study is to evaluate the potential clinical benefit of HSC mobilization followed by high-dose immunoablation and autologous stem cell transplantation versus HSC ...

Nothing lives forever, but compared to other cells in the body, hematopoietic stem cells (HSCs ... the molecular mechanisms ...

Stem cell transplants have become widely used to treat diseases such as cancer, blood disorders and autoimmune diseases where defective stem cells are the root cause. These transplants utilize donor ...

The study provides novel insights into the physiological role and mechanisms of p21 in HSCs during homeostasis independent of its conventional role as a cell cycle inhibitor.

Targeting self-renewal, the process by which stem cells divide ... as the original cell, is another strategy to eradicate LSCs, but unlocking the secrets of both normal HSC and LSC self-renewal ...

A stem cell transplant can be a good treatment for multiple myeloma. A successful transplant gives someone with multiple myeloma new, healthy bone marrow. It replaces the bone marrow harmed by myeloma ...

We discovered that interferon gamma (IFNγ) promotes hematopoietic stem cell (HSC) division and myeloid differentiation in a mouse model of Mycobacterium avium infection (Nature 2010). Furthermore, ...

We are also studying the role of epigenetic modifications, such as DNA methylation, on hematopoietic stem cell (HSC) function and biology. In particular, the lab is investigating the role of DNA ...