Type 2 diabetes (T2D) and obesity (OB) are associated with chronic low-grade inflammation and increased fracture risk. In vitro studies showed that inflammation induces bone erosion and inhibits bone ...

This study presents important findings on the role of CXXC-finger protein 1 in regulatory T cell gene regulation and function. The evidence supporting the authors' claims is solid, with mostly ...

This valuable study examines the effects of side-wall confinement on the chemotaxis of swimming bacteria in a shallow microfluidic channel. The authors present solid experimental evidence, combined ...

Sainsbury Wellcome Centre for Neuronal Circuits and Behavior, University College London, London, United Kingdom ...

Following the decision that eLife will not receive an Impact Factor in 2025, we share an update on how our model is doing ...

This article is dedicated to the memory of Michael G. Rossmann. Dating back to the last universal common ancestor, P-loop NTPases and Rossmanns comprise the most ubiquitous and diverse enzyme lineages ...

In this study, our results uncover the function and mechanism of CHMP5 in the regulation of cell senescence and bone formation in osteogenic cells. Deletion of Chmp5 causes endolysosomal dysfunction ...

The results of central nervous regulation in mice provide a new neural circuit and receptor regulatory mechanisms for the recovery of consciousness after midazolam administration.

Multisensory object discrimination is essential in everyday life, yet the neural mechanisms underlying this process remain unclear. In this study, we trained rats to perform a two-alternative ...

The gut of animals is a complex ecosystem consisting of trillions of bacteria and other microorganisms that are unique to every individual. Infants can inherit their first gut bacteria through vaginal ...

The learning rate (left axis; as reciprocal of the number of trials to acquisition, right axis) plotted against the mutual information (log2 of informativeness) for the 14 groups. Note. The criterion ...

Differences in the ribosomal densities of the two daughters produced by a mother Escherichia coli could explain the asymmetry of aging and growth rate in previously reported such daughter pairs.