The intricate relationship between diet, metabolic disorders, and cancer progression has garnered significant attention in recent years. Excessive calorie intake is known to trigger the production of ...
AAA is strongly associated with obesity, partly due to abnormal dilatation of perivascular adipose tissue (PVAT) in the abdomen, however, direct evidence is still lacking. Cell death-inducing DNA ...
Researchers from Adipo Therapeutics LLC presented data from preclinical studies that aimed to assess the γ-secretase inhibitor ADPO-002 (dibenzazepine) for the treatment of obesity.
The increases in PGC1⍺, PRDM16 and Uncoupling Protein 1 (UCP1) in these studies support ADPO-002's mechanism of action for mitochondrial biogenesis, activation and browning of human white adipose ...