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施一公与宿强最新Nature论文:揭示过敏反应关键机制
从结构角度看,二聚化的FcεRI不利于下游信号的激活,而IgE结合的FcεRI则以单体形式存在,这种构象转变有助于暴露FcεRIβ和FcεRIγ亚基胞内段的ITAMs ...
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