A robust model, such as aProximate TM, is required to study renal dysfunction and perform in vitro kidney disease modeling. This model expresses all transporters specialized in drug, solute, and ...

By competing with aldosterone for receptor sites in distal renal tubules, spironolactone increases sodium chloride and water excretion while conserving potassium and hydrogen ions. The inhibition ...

On 15 November 2024 at the American Heart Association (AHA) conference in Chicago, Illinois, during a cardiovascular seminar session on the topic of emerging therapies for the treatment of ...

On 15 November 2024 at the American Heart Association (AHA) conference in Chicago, Illinois, during a cardiovascular seminar session on the topic of emerging therapies for the treatment of ...

Introduction Physiology of the Renin-Angiotensin-Aldosterone System and Its Pathophysiologic ... Renin is a proteolytic enzyme normally released from the kidney under the stimulus of a decrease ...

The work included in vitro renal transporter studies using Newcells' aProximate TM model, comparing proximal tubule cell flux in rats, dogs, and humans. The data was analyzed to provide a ...

Nephrology is specialty of medicine concerned with kidney physiology, kidney disease, the treatment of kidney problems and renal replacement therapy. Systemic conditions that affect the kidneys (e ...

Kidney cancers are unique for a few reasons. One reason is that renal cell carcinoma can grow directly into the veins that drain the kidney and run up toward the heart. This growth of cancer into the ...