心脏与肺脏是两个高度关联的器官，心脏功能异常会影响肺脏，反之亦然。其中，肺动脉高压就是一种致死率较高的疾病，该病发展到末期会导致右心衰竭，且目前没有很好的治疗手段。在该项工作中，研究人员采用心脏主动脉弓缩窄模型引发肺动脉高压和退行性肺纤维化，模拟了临床上左心疾病引起的肺动脉高压和肺纤维化。其基本原理是，主动脉弓缩窄引起左心室压力增大和左心室肥厚，随后引起左心房和肺动脉和肺静脉压力增大，引起肺动脉高 ...

The underlying mechanisms of loss of distal capillary endothelial cells (ECs) and obliterative vascular lesion formation remain unclear. Method and Results: Our recent single-cell RNA sequencing, ...

Background: Understanding the intricate dynamics of lung microcirculation and capillary endothelial cells (ECs) is crucial for shedding light on both normal physiological processes and the ...

The capillary blocks mainly involved red blood cells and not immune cells, suggesting that the microvascular complications in type 1 diabetes may arise more from endothelial dysfunction than from ...