A recent study evaluates the dosing, safety, and efficacy of telaglenastat and azacytidine to treat advanced myelodysplastic syndromes (MDS), with promising results. Cancer cells, particularly ...

When resistance to or failure of hypomethylating agents (HMAs) occurs in acute myeloid leukemia (AML), depleting a ligase ...

Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration.

Enrollment on track in Phase 2 portion of PYNNACLE clinical trial evaluating rezatapopt as monotherapy in patients with TP53 Y220C and KRAS ...

The DNA methylation inhibitor 5-azacytidine (5-aza), is an approved drug used for treatment of haematological malignancies. The first aim of our work was to investigate the effects of 5-aza treatment ...

Two examples of these types of drugs are 5-azacytidine and 5-aza-2′-deoxycytidine (Egger et al., 2004). These medications work by acting like the nucleotide cytosine and incorporating themselves ...

The appearance and behaviour of cells are determined by the genes expressed in that cell. The abnormal behaviour of cancer cells can thus be explained by invoking quantitative and/or qualitative ...

This manuscript reports important findings on the impact of maternal obesity on offspring metabolism. It presents solid evidence that maternal obesity induces genomic methylation alterations in ...

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Van Andel Institute Chief Scientific Officer Peter A. Jones, Ph.D., D.Sc. (hon), has been elected to the National Academy of ...

In the context of R/R AML, Chen et al. compared the outcome of AML patients relapsing after allogeneic transplant and treated with venetoclax + azacytidine (VEN+HMA) vs those undergoing intensive ...

1 Queen Mary School, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China 2 School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China ...