CTLA-4 (CD152) controls homeostasis and suppressive capacity of regulatory T cells in mice. Arthritis Rheum. 60 , 123–132 (2009). Article CAS Google Scholar ...

Tfr同时表达Treg主调控因子Foxp3和其他Treg相关分子，如CD25和CTLA-4。Tfr表达异常可能导致免疫耐受的破坏，进而诱导自身免疫性疾病的免疫发病机制。

Foxp3 may steer T cells down specific pathways by amplifying and stabilizing features advantageous to Treg differentiation, such as CD25 and CTLA-4 expression, or by repressing features ...

▲ 点击上方蓝字关注CellPress细胞科学 ▲生命科学Life science近日，阿肯色医科大学的湛凤凰教授和南华大学衡阳医学院的夏机良教授联合在Cell Press细胞出版社旗下期刊Trends in Molecular ...

Adagene (ADAG) announced data at the SITC 39th Annual Meeting, taking place in Houston, Nov. 6 – 10, 2024. The two poster presentations ...

As I understand it, COYA 301 promotes Treg function, and CTLA-4 Ig keeps Tregs from senescence and apoptosis, enhancing the therapeutic window. These are the results seen with LD IL-2 + CTLA-4 Ig ...

Will present initial Phase 1C dose escalation data for vilastobart (XTX101), a tumor-activated, Fc-enhanced anti-CTLA-4, in combination with ...

此外，激活的STING信号可增强Tregs、MDSC的动员 ... 肺癌患者放疗后给予Nivolumab治疗，PFS中位数（4.4个月vs 2.1个月，p=0.019）和OS中位数（10.7个月vs ...

They are a treatment for several cancers including melanoma skin cancer and lung cancer. You might also hear them named after the checkpoint proteins they block. For example, CTLA-4 inhibitors, PD-1 ...

Coya Therapeutics, Inc. (Nasdaq: COYA) (“Coya” or the “Company”), a clinical-stage biotechnology company developing biologics intended to enhance regu ...