CBL-514 is the first and only drug to receive EMA Orphan Drug Designation for Dercum's disease treatment. - CBL-514 received both FDA Orphan Drug Designation and Fast Track designation for Dercum's ...

Speed HSPA 42.2/5.76 Mbps, LTE (4CA) Cat18 1200/150 Mbps, 5G 2.4/1.2 Gbps ...

Apoptosis is a genetically controlled form of cell death mediated by enzymes called caspases, and GluR1-induced necrosis is associated with two batches of apoptotic cells. The first batch is found at ...

Department of Biotechnology, Faculty of Applied Sciences and Technology, University of Kerala, Kariavattom Campus, Thiruvananthapuram 695581, Kerala, India ...

The PIDDosome, in turn, activates the enzyme caspase-2, triggering two lethal pathways. First, it activates the protein BID, which directly destroys the mitochondria, leading to cell death.

Figure 2: Effect of various caspase clones on apoptosis induction and co-delivered ... 10 times the LD 50 (50% of the lethal dose) of A/PR/8/34 (H1N1) influenza virus. Following challenge, mice ...

Inflammatory caspases are cysteine protease zymogens whose activation following infection or cellular damage occurs within supramolecular organizing centers (SMOCs) known as inflammasomes.