Researchers have discovered how "leaky" mitochondria – the powerhouses of our cells – can drive harmful inflammation responsible for diseases such as lupus and rheumatoid arthritis. Scientists may be ...
Adult somatic cells typically contain from a few hundred to several thousand mitochondria and this reflects their demands for ATP generated through oxidative phosphorylation 40. The numbers in the ...
In this study, our results uncover the function and mechanism of CHMP5 in the regulation of cell senescence and bone formation in osteogenic cells. Deletion of Chmp5 causes endolysosomal dysfunction ...